F2 and hereditary elliptocytosis: This was followed by the multiple stepwise logistic regression analysis, which identified that white blood cell (OR = 1.972, 95%CIs 1.299–2.993), hemoglobin (OR = 0.978, 95%CIs 0.963–0.992), neutrophils (OR = 0.505, 95%CIs 0.317–0.805), prothrombin time activity (OR = 0.955, 95%CIs 0.936–0.975), blood urea nitrogen, (OR = 1.104, 95%CIs 1.018–1.198), and PPIs usage (OR = 7.867, 95%CIs 2.166–28.575) independently associated with the development of secondary HE (Table 4).