Overlapping clinical and serological abnormalities with SSc such as Raynaud’s, sclerodactyly and antibodies to SCL70 and RNP [47,48,78,79,80] in addition to the antibodies which overlap with Sjögren’s, anti-Ro (SSA) and anti-La (SSB) are also risk factors. This evidence concerns the gene CALR and systemic sclerosis.