IL-37 mRNA levels were found to be increased by 12-fold in samples from LUAD (n = 524) compared to those from non-LUAD individuals (n = 486, Mann–Whitney p = 3.83 × 10−59), and by 11-fold in tumor compared to paired adjacent normal tissues from LUAD individuals (n = 57; p = 3.81 × 10−8) (Figure 2A). Here, IL37 is linked to neoplasm.