What is more, IL-37 secreted from HCC cells enhances the expression of MHC-II, CD86, and CD40 surface molecules and the secretion of IL-2, IL-12, IL-12p70, interferon-a (IFN-α), and IFN-γ cytokines by DCs, which is, in turn, associated with an increased proportion of IFNγ+CD8+ T cells [20]. This evidence concerns the gene IFNG and hepatocellular carcinoma.