First, it acts as an anti-angiogenic factor; its expression by cancer cells suppresses the tubule formation of human umbilical vein endothelial cells (HUVEC) cells in vitro, decreases the expression of matrix metallopeptidase 2 (MMP2) and vascular endothelial growth factor (VEGF) in SK-Hep-1 cells, and inhibits tumor angiogenesis in a murine model of HCC [22]. The gene discussed is VEGFA; the disease is hepatocellular carcinoma.