Lung cancer specimens were further analyzed based on their specific type: either lung adenocarcinoma (LUAD) or lung squamous carcinoma (LUSC); the former exhibited increased IL-37 expression levels compared to the latter (12.85 ± 44.05, n = 500 vs. 0.25 ± 1.79, n = 494, respectively; Mann–Whitney p = 0.0001). This evidence concerns the gene IL37 and lung cancer.