The results identify six high-confidence GBM genes, HLA-DRA, CD44, SLC1A5, EGFR, ITGB2, PTPRJ, which were significantly upregulated in GBM. High expression of CD44, PTPRJ, and HLA-DRA was significantly associated with poor disease-free survival. The gene discussed is HLA-DRA; the disease is glioblastoma.