Based on currently available TCGA and CGGA data, the most frequently reported molecular/genomic features in glioma are IDH, TP53, ATRX, PTEN, EGFR, CIC, MUC16, PI3K3CA, NF1, PIK3R1, FUBP1, TB1, NOTCH1, and TERT (Tasci et al., unpublished data) [41], and given their capture and potential for analysis, these can help make connections to MGMT, IDH, and other markers and clinical outcomes. The gene discussed is MGMT; the disease is central nervous system cancer.