The proneural subtype has more frequent mutations in PDGFRA (platelet-derived growth factor receptor alpha), the neural subtype has frequent mutations in CD44 and VEGF (vascular endothelial growth factor), classical has frequent EGFR amplification, while the mesenchymal subtype has NFI (neurofibromatosis type 1) and PTEN (phosphatase and tensin homolog) mutations [5,13]. The gene discussed is PTEN; the disease is neurofibromatosis type 1.