Several neurodegenerative diseases such as Alzheimer’s disease (AD), progressive supranuclear palsy, frontotemporal dementia, as well as various types of parkinsonism and synucleinopathies, are characterised by the occurrence of insoluble, highly phosphorylated Tau at (Ser396) [76,77,78,79]. This evidence concerns the gene MAPT and neurodegenerative disease.