PSEN1 and Alzheimer disease: Different AD models display an increased physical interaction between ER and mitochondrion [123,151,153,154,155,156], even before Aβ plaque deposition [123,157], although other reports indicate a decrease in ER-mitochondria contact sites in cells treated with Aβ oligomers [158], or no effect by the expression of PSEN1 mutations [153].