Contrasting results on mitochondrial Ca2+ signaling have also been published regarding AD-linked PSEN1 mutations, with data sustaining the mitochondrial Ca2+ overload hypothesis in neurons isolated from PS1-transgenic mice [147], and others reporting impaired mitochondrial Ca2+ uptake in cultured rat hippocampal neurons transfected with PSEN1-M146V [148]. Here, PSEN1 is linked to Alzheimer disease.