A detailed analysis of published data detected nine typical tumor-agnostic mutations, including TP53 (tumor suppressor protein p53 gene), KIT (tyrosine-protein kinase gene), KRAS (kirsten rat sarcoma viral oncogene homologue gene), BRCA1 (breast cancer gene 1), ATM (ataxia telangiectasia gene), JAK2 (janus kinase 2 gene), NTRK3, FGFR3 (fibroblast growth factor receptor 3 gene) and EGFR (Figure 1). Here, JAK2 is linked to neoplasm.