However, as the beneficial effects of nonselective cannabinoids are usually accompanied by the undesirable psychoactive effects mediated by CB1R, the major pharmacological approaches against multiple sclerosis are directed towards selective CB2R agonists that target the CB2R on microglial cells and consequently inhibit the release of various pro-inflammatory mediators and cytokine-mediated demyelination process [265]. Here, CNR1 is linked to multiple sclerosis.