TP53 and neoplasm: Conversely, centromeric to miR-22, there are several known tumor suppressor genes, such as miR-212 (Chromosome 17: 2,050,271–2,050,380), miR-132 (Chromosome 17: 2,049,908–2,050,008) and HIC1 (Chromosome 17: 2,054,154–2,063,241), which are all in the same cluster, and are very close to each other, as well as to TP53 (Chromosome 17: 7,661,779–7,687,538) (Figure 1).