In this context of defining the normalization window in experimental models of different tumors, it was found that the signal mediated by the Ang1/Ang2-Tie2 axis is important for the recruitment of pericytes for tumor vessels and that the overexpression of Ang2 may negate the benefit of anti-VEGF therapy by abrogating Ang1-mediated vessel normalization [74]. This evidence concerns the gene ANGPT1 and neoplasm.