SMC4 and meningioma: Among the DMRs and multiple gene hits (Table 3 and Table S2, Figure 2), notable hypomethylated regions in high-grade meningiomas were linked to cell cycle, cell differentiation, and cell fate genes, such as SMC4/miR16 (four CpGs spanning 1036 bp, 41% average methylation differential (AMD)), PATJ (three CpGs spanning 155 bp, 31% AMD), and TP63 (nine CpGs spanning 650 bp, 23% AMD; coding for the tumor protein p63).