More recently, several genes with recurrent mutations were identified in meningioma, including proapoptotic E3 ubiquitin ligase TNF receptor-associated factor 7 (TRAF7), pluripotency transcription factor Kruppel-like factor 4 (KLF4), proto-oncogene v-Akt murine thymoma viral oncogene homolog 1 (AKT1), Hedgehog pathway-signaling member “smoothened” (SMO), and phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit A (PIK3CA). This evidence concerns the gene KLF4 and meningioma.