Altered platelet function has also been reported, but data are not conclusive yet; Egan et al. [36] reported decreased platelet aggregation in MM patients but no link between platelet hyporeactivity and paraprotein levels, and Sullivvan et al. reported platelet hyperactivation with increased CD63, PAC-1 expression and annexin V in resting platelets of MM and MGUS patients compared to healthy controls [37]. This evidence concerns the gene CD63 and Miyoshi myopathy.