Even though it was reported that this interaction is independent of AURKA kinase activity, a study by Brockmann et al. demonstrated that inhibitors of AURKA kinase activity could also disrupt the interaction between AURKA and FBXW7α, leading to N-MYC destabilization and tumor regression in a mouse model of N-MYC-driven NB xenograft [119]. This evidence concerns the gene AURKA and neuroblastoma.