A functional connection between Rho-associated coiled-coil containing protein kinase 2 (ROCK2) and YAP in regulating OS cell migration and metastasis formation has been described by Zucchini et al. They reported that ROCK2 silencing induced a reduction in the nuclear expression and transcriptional activity of YAP and significantly reduced tumor growth, and eradicated the metastatic potential of OS cell lines [80]. Here, YAP1 is linked to neoplasm.