TAMs secrete various cytokines and growth factors, including interleukin (IL)-10, transforming growth factor-beta (TGF-β), vascular endothelial growth factor (VEGF), and C-X-C motif ligand (CXCL) 12 to drive cancer progression through immune suppression, tumor angiogenesis, invasion and metastasis [16,17,18]. This evidence concerns the gene VEGFA and cancer.