NPM1 and acute myeloid leukemia: Among the 63 IDH2-mutated AML patients, 22 had concurrent NPM1 mutation RT-qPCR MRD for comparison, 17 had good concordance between IDH2 LNA-qPCR MRD, NPM1 RT-qPCR (Figure S6), and marrow blasts, while five patients had persistently high IDH2 LNA-qPCR MRD but with low NPM1 RT-qPCR MRD and marrow blasts <5% (Figure S7a).