KCNN4 and central nervous system cancer: This might explain why a radio-sensitizing effect of TRAM-34 alone and an additive radio-sensitizing effect of TRAM-34 combined with temozolomide treatment was only apparent in glioma stem cell-enriched SMA-540 cells (see Figure 6D–E) which was the culture with the highest KCa3.1 mRNA abundance (see Figure 3B).