Compared to TNBC, Luminal-A (OR 0.63, CI 0.51–0.79, p < 0.001) and Luminal-B/HER2-Negative (OR 0.78, CI 0.64–0.94, p = 0.010) breast cancers were less likely experience HER2 status discordance between CNB and SES specimens. The gene discussed is ERBB2; the disease is breast carcinoma.