In oncology, the PD-1/PD-L1 axis activation induced by PD-L1-expressing tumor cells interacting with PD-1-expressing tumor-infiltrating lymphocytes (TILs) is one of the most studied immune evasion strategies played by cancer, paving the way for the development of immunotherapeutic approaches based on the blockade of these molecules [28]. This evidence concerns the gene CD274 and cancer.