SSTR2 and cancer: When the downregulated DEGs from three SSTR2-OVER cells were pooled and compared with hallmark molecular signatures, the result revealed that 10 of 18 induced pathways in SSTR2-KO SNU638 cells were significantly inhibited in SSTR2-OVER cells (Figure 6A), especially in SSTR2-OVER AGS and MKN45 cells (Figure 6B), suggesting that SSTR2 may inhibit cell signaling for cancer-related inflammation.