Zymographic analysis of MMPs from HCT116, HT-29, and SW480 CRC cell lines showed that deflamin exerts an inhibitory role on the activity of both MMP-2 and MMP-9 in all cell lines tested, displaying the greatest effect on SW480 cell line (a reduction of about 75% of MMPs activity at a deflamin concentration of 80 μg/mL, *** p < 0.001, Figure 2C). Here, MMP2 is linked to colorectal carcinoma.