Furthermore, the gene that codes for HER3, ERBB3, has been included as both part of a two gene signature with BRCA1 in which both genes are regarded as independent risk factors in the IASLC/ATS/ERS classification of early-stage lung adenocarcinoma and a five gene signature that is predictor of OS and relapse-free survival (RFS) in NSCLC patients [105,106]. Here, ERBB3 is linked to lung adenocarcinoma.