In contrast to blood VEGF-A levels, lower VEGF-A expression in the tumour was associated with more progressive disease as best response p = 0.008; PFS HR: 1.166 95% CI 1.018–1.336 p = 0.027 and OS: HR:1.189 95% CI: 1.036–1.364 p = 0.014. Here, VEGFA is linked to neoplasm.