While the available data do not directly or mechanistically prove a causative role of elevated NF-κB activity in prostate cancer cells in therapy resistance or tumor progression, our combined experimental and computational analyses strongly suggest that androgen deprivation results in upregulation of NF-κB activity, which has been demonstrated in numerous studies to have a protumorigenic role. The gene discussed is NFKB1; the disease is Familial prostate cancer.