We also identified several genes supporting MDSC recruitment that were highly expressed in this population, including C-X-C motif chemokine receptor 2 (Cxcr2) and Csf3, as well as increased levels of the transcription factors Stat3 and CCAAT enhancer binding protein beta (Cebpb) which are involved in regulating the expansion of MCSC in cancer and the expression of immunosuppressive factors [1,32] (Figure 4d). This evidence concerns the gene STAT3 and cancer.