STAT1 and neoplasm: In a murine B16-gp33 model, HDACi MS-275 induced NOS2 (Nitric Oxide Synthase 2)/Reactive Oxygen species (ROS) secretion and activated pro-inflammatory gene signatures which reduced the immunosuppressive function of tumor-infiltrating myeloid cells, by inducing their cell death in an IFN-γR/STAT1 signalling dependent manner [129].