The multivariate linear regression on global health status, an indicator of overall HRQOL, revealed that serum albumin (<40 g/L: β = −13.29, 95% CI = −21.78, −4.79, p = 0.002) and the interaction between sarcopenia and the surgical approach (Sarcopenia laparoscopic surgery Group: β = 26.68, 95% CI = 9.96–43.39, p = 0.002; Non-sarcopenic open surgery group: β = 16.88, 95% = 2.31- 31.45, p = 0.024; non-sarcopenic laparoscopic surgery group: β = 20.97, 95% CI = 6.36–35.59, p = 0.005) were independent predictors of global health status (Table 3). This evidence concerns the gene ALB and sarcopenia.