The importance of sialoglycans in PDA was confirmed when the decrease of PDA sialylation, in particular of sLex/a tumor antigens, achieved by the knockdown (KD) of ST3GAL3 and ST3GAL4 impaired PDA cell migration, invasion, and E-selectin-dependent adhesion in vitro [15]. This evidence concerns the gene ST3GAL4 and Patent ductus arteriosus.