SELE and neoplasm: Similarly, Natoni et al. and Rillahan et al. demonstrated that a reduction of sLex and sLea caused by Ac53FaxNeu5Ac treatment led to a significant decrease in the interaction between tumor cells and E-selectin in human leukaemia and melanoma cells [19,20]; moreover, Soyasaponin-I, which is another ST inhibitor, was described to block sialylation and inhibit tumor cell adhesion to endothelial monolayers [21].