For instance, tumor-activated SCs up-regulated the expression of the STAT3, SOCS3, BCL6, ELF3, IGF2, IL32, RUNX1, and NEUROD2 genes and inhibited the expression of the CHAC2 and BOLA2B genes in SCLC cells in vitro. This evidence concerns the gene CHAC2 and small cell lung carcinoma.