SPEM2 and small cell lung carcinoma: For instance, incubation of SCLC cells in the activated SC-conditioned medium up-regulated expression of the STAT3, SOCS3, BCL6, ELF3, IGF2, and IL32 genes, in addition to the KRT6A, PLA2G2A, CEACAM1, KRT14, SPEM2, GABRP, and A2M genes, while the expression of the ACTA1 and MYH7 genes was down-regulated.