The inflammatory component of a developing neoplasm often includes a diverse leukocyte population—for example, neutrophils, dendritic cells, macrophages, eosinophils, mast cells, and lymphocytes - all of which secrete a wide array of cytokines and cytotoxic mediators including reactive oxygen species, serine, and cysteine proteases, MMPs, membrane-perforating agents, as well as soluble mediators of cell killing, such as IFNs, TNF-α, and cytokines [98,99]. Here, TNF is linked to neoplasm.