AGER and breast carcinoma: We used RCS to flexibly model and visualize the relation of AGEs and sRAGE with breast cancer (Figure 1B–D) and observed that AGEs and AGEs/sRAGE-ratio had a non-linear positive correlation with the risk of breast cancer (Pnonlinear < 0.001), which increased with higher concentrations of AGEs and AGEs/RAGE-ratios, with the risk reaching plateaus at 7.1 ng/mL of AGEs.