MITF and melanoma: Since a dual classification of transcriptional states nowadays falls restrictive, new progressive differentiation subtypes have been described and subsequently listed: hyperdifferentiated cells, melanocytic proliferating cells, transitory-intermediate migrating cells, therapy-induced starved-like melanoma cells, neural crest stem cell-like (NCSC-like) cells, and MITF-negative undifferentiated cells, respectively (Figure 1) [16,48].