CEACAM5 and metastatic malignant neoplasm in the lymph nodes: In the univariate analysis, lymph node metastasis positive (hazard ratio (HR) = 1.87; 95% confidence interval (CI), 1.151–3.038; p = 0.012), elevated value of serum CEA (>4 ng/mL; HR = 1.755; 95% CI, 1.092–2.833; p = 0.021), and increased value of CA19-9 (>135 U/mL; HR = 1.850; 95% CI, 1.112–3.049; p = 0.016) were associated with increased risk of overall survival, while the presence of S-TLSs (HR = 0.472; 95% CI, 0.284–0.784; p = 0.004) was the only variable that correlated with reduced risk (Table 3).