MM is still an incurable disease, and the majority of patients will eventually relapse, which manifests as the reappearance of M protein in blood or urine, increased bone marrow plasma cell percentage, hypercalcemia, new osteolytic lesions or soft tissue plasmacytoma. This evidence concerns the gene MYOM2 and short stature-onychodysplasia-facial dysmorphism-hypotrichosis syndrome.