The WGS analysis of cfDNA revealed multiple mutations and CNAs consistent with PCa tissue analyses: BRCA1/2, TP53, SPOP, ATM, APC, and CHEK2 mutations, as well as CNAs in TMPRSS2-ERG and RB1, and PTEN deletions, AR and MYC amplification (Figure 2) [55,56,143,144,145,146,147,148,149,150]. This evidence concerns the gene RB1 and posterior cortical atrophy.