In a proteomic analysis of urinary exosomes, eleven proteins (SCIN, AMBP, FABP5, CHMP4C, CHMP2B, BAIAP2, GRN, SYTL2, CALR, CHMP4A, and DNPH1) showed significant enrichments in the urine samples of PCa patients versus patients with negative biopsy [193]. The gene discussed is CALR; the disease is posterior cortical atrophy.