NDP and posterior cortical atrophy: Figure 2 shows known driver mutations and CNAs detected in tissue that are involved in the initiation, as well as the progression, of PCa. Furthermore, mutations and CNAs in the mitochondrial genome (mtDNA), resulting in the dysregulation of mitochondrial homeostasis, can play a role in tumor initiation, growth, and metastasis. Mutations and CNAs in mitochondrially encoded tRNA, CO1, ATP6, PC3, and ND genes can be potential prognostic biomarkers that may improve the early detection of aggressive PCa [54].