EGFR and head and neck squamous cell carcinoma: For instance, HPV (i.e., HPV+ oropharynx HNSCC has a more favorable prognosis compared to HPV), EBV (i.e., EBV+ has a worse prognosis than EBV-), protein p16 (i.e., p16+ HNSCC present poorer differentiation but better prognosis), and EGFR (i.e., overexpression is correlated with increased recurrence and decreased survival) are some of the most relevant predictive and/or prognostic markers in HNSCC [73,74].