In contrast, we observed no difference between the mRNA level of PRKCD in BRAFi-sensitive and A375-R1 or A375-R2 melanoma cells and no detectable PRKCB mRNA in either BRAFi-sensitive A375, A375-R1 or A375-R2 melanoma cells (Figure S8A). The gene discussed is PRKCD; the disease is melanoma.