WNT5A and melanoma: As shown in Figure 2, we observed, for the first time, significant increases in the levels of total MARCKS and phosphorylated (Ser-159/163) MARCKS in all four BRAFi-R melanoma cell lines when compared to their BRAFi-sensitive counterparts, suggesting a possible role for WNT5A-MARCKS signaling in mediating the increase in the invasive and metastatic behavior of BRAFi-R melanoma cells (Figure 1C,D and Figure 2).