AR and Familial prostate cancer: For this purpose, the relevant literature was searched through an automatized search in the PubMed bibliographic database published between 2000 and 2022 using the combination terms: “prostate cancer” OR “androgen receptor” OR “castration resistance” OR “metastatic prostate cancer” OR “antiandorgens”, “novel hormone agents”, “androgen receptor signaling inhibitors” OR “resistance mechanisms”.