TCF4 and hepatoblastoma: In summary, the studies of the ph-S675-β-catenin-TCF4-CEGRs/ALCDs pathway in HBL patients, in hepatoblastoma cell lines HepG2 and Huh6 and in PDX models of HBL, demonstrated the essential role of the ph-S675-β-catenin-TCF4-CEGRs/ALCDs axis in the development of aggressive HBL.