WEE1 and fibrolamellar hepatocellular carcinoma: Studies of molecular mechanisms in fibrolamellar hepatocellular carcinoma (FLC) found that the FLC-specific fusion DNAJB1-PKAc protein kinase phosphorylates β-catenin at S675, resulting in an elevation of ph-S675-β-catenin-TCF4 complexes, oncogene activation, and activation of fibrotic genes via CEGRs/ALCDs [20].