The tumor volume and weight of oe-ALKBH5 + sh-NC-treated mice were increased but opposite results were noted in the presence of oe-ALKBH5 + sh-UBE2C (Figure 6C,D), suggesting that the tumor-promoting effect of ALKBH5 can be partially reversed by the silencing of UBE2C. This evidence concerns the gene ALKBH5 and neoplasm.