HIF1A and cancer: Some HIF-1 inhibitors, such as PX-478, PMX290, and FK228, were shown to enhance the antitumor effects of chemo/radiotherapy by inducing apoptosis in pancreatic ductal adenocarcinoma (PDAC) and various other cancers [140,141,142,143,144,145,146,147,148,149,150,151].