ERBB3 and breast cancer: In breast cancer (BCa) cells, ZNF217 directly upregulates HER3 gene expression, facilitating the formation of the well-known HER2/HER3 oncogenic cassette, which results in the activation of the mitogen-activated protein kinases (MAPK) and phosphoinositide 3-kinase (PI3K)/AKT survival pathways [11].