In addition to the two aforementioned axes (lncRNA-ATB/miR-200c/ZNF217/TGF-β2 and MALAT1/miR-141-3p/ZNF217/TGF-β2), both involved in the activation of the TGF-β signaling pathway and EMT, ZNF217 is part of additional intricate ceRNA-driven regulatory circuits involved in tumor progression (Figure 4A). The gene discussed is MALAT1; the disease is neoplasm.