EGFR and central nervous system cancer: Amplification and deletion mutants of the epidermal growth factor receptor (EGFR) gene are frequently found in glioma cancer cells; in particular, the truncation of the EGFR protein extracellular domain, EGFR variant III (vIII), generated by truncation of exons 2 to 7, was only found in GBMs and occurs at an overall frequency of 25–64% [6,7].