Based on our recent study and substantial evidence in the literature about the role of EGFR and PUMA on mitochondria activity, we wondered whether the iPA-induced death of GBM cells was due to an alteration of the mitochondrial metabolism mediated by a modulation of the protein levels of EGFR/EGFRvIII and PUMA or by their localization on the mitochondria. The gene discussed is EGFR; the disease is glioblastoma.