GBM cells transfected with Y845F variant of EGFR/EGFRvIII as well as iPA-treated ones showed a significantly reduced oxygen consumption rate as compared to control cells (Mock) (Figure 5A–C, left panels), suggesting that the Y845 phosphorylation of EGFR is important for the mitochondrial respiration. Here, EGFR is linked to glioblastoma.