APC and adenoma: When transgenic mice with APC deletion (APC−/−) were given 400 μL of 25% HFCS solution via oral gavage, providing calories from HFCS similar to human consumption of less than 355 g of SSB, for 8 weeks, the number of large adenomas (>3 mm in diameter) and high-grade tumors significantly increased in the HFCS group compared to a control group.