MEG3 could also trigger apoptosis in ESCC and CRC by increasing endoplasmic reticulum (ER) stress-related proteins, including glucose-regulated protein 78 (GRP78), activating transcription factor 6 (ATF6), protein kinase R-like endoplasmic reticulum kinase (PERK), and C/EBP-homologous protein (CHOP), leading to enhanced caspases-9 and -3 cleavages [97,98]. This evidence concerns the gene MEG3 and esophageal squamous cell carcinoma.