Furthermore, MEG3 competitively interacts with miR-27a as the ceRNA of PH domain and leucine-rich repeat protein phosphatase 2 (PHLPP2) mRNA, promoting PHLPP2 protein translation and inhibiting c-Jun phosphorylation and c-Jun-mediated c-Myc mRNA transcription, thereby impairing invasion and lung metastasis of bladder cancer cells [71]. This evidence concerns the gene JUN and urinary bladder cancer.