PTEN and hepatocellular carcinoma: Furthermore, by sponging its target miRNAs, such as miR-10a-5p, MEG3 can cause G0/G1 cell cycle arrest and enhance the expression of PTEN, Bcl-2-associated X (Bax), and p53 protein in hepatocellular carcinoma (HCC) [82], or by sponging miR-7 and miR-376, leading to the downregulation of miR-7/RAS like family 11 member B (RASL11B) and miR-376/protein kinase D1 (PKD1) axis [62,63].