For low-SETD7 tumours, PARP-1 was present in all datasets from CPTAC; Cullin 1 in the total proteome; centromere protein C, HIV Tat (HTATSF1), RIO1, DNMT1, and TTK in total and phosphoproteome; Msx2-interacting protein (SPEN), catenin beta-1 (CTNNB1), TAF7, PPP1R12A, and SUV39H1 in phosphoproteome; MED1 and YY1 in phosphoproteome and acetylproteome; and Sam68 (KHDRBS1) and STAT3 in acetylproteome. The gene discussed is RIOK1; the disease is neoplasm.