To investigate whether SETD7 differential expression was correlated with clinically relevant mRNA and protein signatures, we first analysed datasets in cBioPortal where this information was available (hypoxia scores were available for the TCGA PanCancer cohort, and stromal, immune, and stemness scores for CPTAC cohort), and as a second approach, we used a deconvolution method in R to further explore the tumour microenvironment infiltration mRNA signatures in the TCGA-BRCA cohort. The gene discussed is SETD7; the disease is neoplasm.