R-CHOP: Low GAPDH expression level correlates to DLBCL patients’ resistance to R-CHOP treatment [418,430], and their sensitivity to metabolic inhibitors targeting mammalian target of rapamycin complex 1 (mTORC1) signaling, OxPhos and glutaminolysis [418]. The gene discussed is DDIT3; the disease is diffuse large B-cell lymphoma.