HAVCR1 and neoplasm: Subsequently, investigators performed a retrospective analysis of ASSURE patients (with blood available following a total CRN) and reported an association with higher baseline plasma detection of KIM-1 and worse OS in a multivariable accelerated failure time (AFT) model, after adjustment for age, sex, performance status, Fuhrman grade, nodal stage, tumor stage, presence of sarcomatoid features, and tumor histology (survival time ratio 0.71 for 75th vs. 25th percentile of KIM-1; 95% CI, 0.56–0.91; p < 0.001) [46].