ANKRD1 and familial dilated cardiomyopathy: To address the role of ANKRD1 in the pathophysiology of MC-induced DCM, we used a well-established experimental autoimmune myocarditis (EAM) model mimicking human fulminant MC in the acute phase and human DCM in the late phase [23,24], and evaluated the cardiac stress response in ANKRD1-deficient mice at DCM stage.