CSRP3 and familial dilated cardiomyopathy: The genetic ablation of Ankrd1 in MLP (muscle LIM protein) knockout mice (the genetic model of DCM) directly inhibits maladaptive protein kinase C alpha (PKCα) (negatively regulated by MLP) signalosome formation (regulating cardiac contractility and propensity toward HF), thereby preventing morphological, functional, and molecular development of the DCM phenotype [21].