That is, cells undergoing malignant progression are characteristic of expressing NOX1, catalase, and SOD that can protect them from being attacked by exogenous reactive oxygen and nitrogen species (RONS) [127]; the unique composition of CAP can synergistically sensitize tumor cells to external redox perturbation by generating high concentrations of secondary singlet oxygen in tumor cells that inactivates catalase and promotes aquaporin-mediated H2O2 influx towards activated RONS-triggered cell death [128,129]. The gene discussed is BRD4; the disease is neoplasm.